
Acne and Acne Laser Treatments
Acne is an extremely common condition affecting probably around 85% of adolescents and adults at some time in their lives. The common wisdom when you’re 14 years old with mega eruptions of acne on your face, back, shoulders and chest is that it will fade with time and you’ll “grow out of it”. Very many people don’t and in fact persisting acne into adulthood is common and also traumatic and troublesome. Acne is socially debilitating, depressing and associated with suicide.
Acne patients are generally long suffering and often despondent by the time they seek medical assistance. They need fairly gentle encouraging handling and with combination therapies will achieve good improvements in a short time frame. One of the main determinants of success in my experience is persuading patients to stick with a treatment protocol. Whilst its not true to say that sticking to any treatment is as successful as another, persistence brings better results.
The size of the problem can be gauged partly by looking at how many web searches are made for acne-related terms in any one month. In March 2010 a total of nearly 500,000 searches were made for acne, acne treatment and acne medicine via Yahoo. By anybody’s terms this suggests a huge problem. In the USA the estimated cost of acne in the USA is thought to be in excess of $1 billion with $100 million spent on over the counter remedies.
Social and psychological stigma associated with acne and acne scarring is colossal, with very many people withdrawing from social activity such as sports as a result. Men are inhibited from taking off their shirts in public and many of our male patients have withdrawn from high-level athletics, football and swimming as a direct consequence of acne. This generally leaves them regretful and in some instances resentful. One of the most annoying things patients report is that everybody has a solution which they are keen to offer. Drinking Guiness, sunlight, steam rooms, homeopathy, mysterious herbs ordered over the internet are all candidates put forward by well-meaning but irritating friends and relatives.
Acne is quite a complicated condition. Children rarely, if ever develop acne. Rather, it begins as puberty develops, mainly in response to the sudden development of super-doses of testosterone in both boys and girls. Acne is described in the medical literature as a follicular disease6. This means that the individual skin hair follicles become larger, produce more oil and more skin cells and then block. The blockage causes the glands to slowly accumulate oil and miscellaneous skin debris. This then makes the glands larger and eventually they are colonized with a bacteria, Propionibacterium acnes.
Teenagers with their oily skin are ideal breeding grounds for the acne bacteria. Unfortunately so are some adults who seem to be predisposed to continuing acne. Men who use anabolic steroids will often experience dramatic breakouts – effectively going through puberty all over again, each time they use.
The invasion of the acne bacteria starts a fabulous cascade to dermal hell. The immune system recognises the bacteria as foreign and lymphocytes flood into the follicles and peri-follicular area. This results inflammation and the follicle will rupture releasing bacteria, oil (sebum) and skin cell debris into the nearby dermis. The cascade ratchets up a notch with infiltration with neutrophils, lymphocytes and foreign body giant cells producing papules, pustules and nodular swellings7.
Diagnosing acne rarely presents a problem. Patients, their mothers, boyfriends and girlfriends have already correctly identified the disease before they come anywhere near a doctor. They’ve also usually spent quite a bit on miscellaneous remedies in the pharmacy, though rarely for long enough to make any sustained improvement.
Treatment
Standard treatments haven’t changed much in the last thirty years or so quite frankly and they remain mostly unsatisfactory from a patient’s point of view.There are though some glimmers of light on the horizon.
The mainstay of treatment remains oral antibiotics which require long term usage over many months. It’s estimated though that around 65% plus of acne bacteria in UK patients is resistant to commonly used antibiotics such as tetracyclines (25%) and erythromycin (50%). In addition, such antibiotic usage sometimes will trigger development of resistant commensal organisms which may then superinfect pre-existing acne lesions exacerbating the condition and allowing for paradoxical loss of disease control.
Whilst for some patients the response to oral antibiotics is good, for many it is lacklustre at best. This, coupled with increasing reluctance to take antibiotics long term, common GI side effects and photosensitivity reactions is making oral antibiotic treatment a poor option.
New formulations of antibiotics have successfully removed the “antibacterial” part of the medication whilst retaining the anti-inflammatory part which is thought to be very important. Medications such as lymecycline are highly effective and very well tolerated.
Topical antibiotics are commonly used also but in my experience are poorly effective, active only on the well applied areas and some of the preparations may give a fluorescent glow in ultraviolet light – difficult for young people in nightclubs. There are other preparations like benzoyl peroxide which have a good antibacterial effect but can be extremely irritating to the skin and will bleach coloured items such as clothing. For large hard to reach areas such as the back they are less than practical.
Retinoid creams and gels will act to regulate the follicle function and restore normality. They are useful in active inflammatory acne and also to reduce comedone formation. They will improve the general tone and look of the skin. In darker skins where inflammatory lesions leave dark hyperpigmented areas they will act to reduce the hyperpigmentation. Coupled with “blender” creams containing hydroquinone such as the Obagi Nu-Derm Blender, the dark scarred areas can be reduced markedly. Retinoid creams are prescription only items and a doctors prescription is necessary.
Roaccutane has attracted a great deal of attention recently. It works very well indeed in severe acne, but because of the side effect profile it is limited to prescription by hospital dermatologists and for very severe acne only. It works by attacking all the various pathways that lead to acne formation. It reduces the size of the follicles, reduces the formation of oil and blockages in the skin and effectively kills off the bacteria causing acne. The result is an extremely potent treatment. However, there are possible psychiatric side effects. This is difficult to tease out fully because acne alone is known to cause depression and lack of confidence. Recent evidence seems to suggest that the severity and length of duration of acne is more relevant in suicidal thoughts than the medication used to treat acne.
At Freedomhealth we’ve started using the Sciton BBL laser. The laser has two effects. The first is that the immediate impact of the laser beam on the acne bacteria is to kill the organisms, an effect similar to that achieved by exposure to sunlight or UV light. This seems to be mediated by an oxygen liberating effect with porphyrin containing organisms subjected to particular wavelengths of light. In addition the laser seems to have a immune modulating effect such that the initial response and the body’s cascade reaction to the acne sequence might be reduced leading to long term improvement overall.
Our own results at Freedomhealth have been intensely encouraging with the overwhelming majority of patients treated experiencing significant improvement with one to two treatments. It is common to experience a very immediate improvement probably due to the bacteria killing effect of the laser, followed by a short relapse 7 or so days post treatment and then a sustained improvement thereafter.
Summary
There is no doubt that acne is a demoralizing and depressing condition whether it’s on the face or back or both. There are some very basic rules to follow which will minimize the damage, because its not only the red spots which can disfigure but the scars which result from inappropriate picking an squeezing.
Try and keep your fingers away from your spots. If you must squeeze, then restrict it to the spots with yellow heads or blackheads only. Don’t squeeze the blind red ones because you’ll just double the result. Wash the to-be-squeezed areas well and scrub your finger nails with a brush before attempting the squeeze.
Dietary factors are said to be irrelevant but from personal experience I know that certain foods make my acne worse. Try and identify your own troublemakers and keep them to a minimum.
Seek advice from an interested doctor early rather than late. This will save you months of angst and also a fair amount of money in terms of potions and lotions.