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  #1  
Old 05-11-2011, 08:22 PM
Rio
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Default False Negatives and Window Periods

Hi,

Hope you are well?

Last April (2010) I had a high risk exposure with a gay man (who apparently was HIV+ not on meds, which I recently found out) when the condom broke and he ejaculated inside me. I was also infected with other 2 STDs from the same incident.

I had 2 HIV tests after at 6 & 7 weeks, The specialist doctor at the time adviced a repeat test at 3 months but the health care assistant adviced that tests are/were conclusive but a 3-month HIV test was also offered but I refused to be taken.
The tests were showing : Ag: not detected; Ab:not infected.
Since I didnt thought the guy was positive at the time I put it all behind me.

The last two months I have diagnosed twice with oral thrush accompanied with blisters at the corners of my mouth which has been treated but returned within 3 weeks.
GP looked at the history and "begging" me to have a HIV test since returning oral thrushes is first sign of HIV.

Do you think I need a follow up test?
I know you argue in your site that for DUO tests, 28 days is the conclusve window period unless you have symptoms (fever, throat pain, rash) or specific exposure (which I assume this describes an exposure with HIV+ individual).
Is there a 0.2% chance the tests to be false negatives? Which means 1 false negative on every 1,000 tests?
Is the oral thrush a symptom of HIV after 12 months?

Hope it makes sense,
Warm Wishes
PP
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  #2  
Old 05-15-2011, 03:48 PM
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Default False negatives and Window periods

Hello

You have had a very significant exposure and you now have symptoms which are suspicious.

You do need to have an HIV test. Your GP is correct and frankly, I don't see any reason why you don't have an HIV test unless you agree with him that there is a distinct risk you are HIV positive and are frightened about it.

You've said:-

Quote:
Do you think I need a follow up test? yes, most definitely
I know you argue in your site that for DUO tests, 28 days is the conclusve window period unless you have symptoms (fever, throat pain, rash) or specific exposure (which I assume this describes an exposure with HIV+ individual). yes - but obviously we never really know the status of the other person/s until they have been tested
Is there a 0.2% chance the tests to be false negatives? Which means 1 false negative on every 1,000 tests?In your case with this history I would be highly suspicious about the thrush - the ideal obviously would be to have thrush from an incidental cause - but you do need a test
Is the oral thrush a symptom of HIV after 12 months? it could be I'm afraid - you do need to have an HIV test again. If you are HIV positive then treatment will dramatically alter the outcome and will dramatically improve your health. Your GP is absolutely right - you do need an HIV test
best regards, Sean
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Old 05-15-2011, 09:08 PM
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Dear Dr,

Of course I am scared.

I put it behind me cause I believed 4th gen tests are conclusive after six weeks, even earlier as per your website

Don't you think that it's a bit early - after 12 months - to develop thrush because of HIV?

Lastly, what went wrong with the testing and possibly didn't pick up the infection? Have you seen a negative result at seven weeks to turn positive later on?

Does the thrush means that I have to start medication asap?

Thank you
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Old 05-16-2011, 07:33 AM
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Default False negatives and window periods

Hello

Quote:
Of course I am scared.I know - we see this very frequently unfortunately - but and its an important but - if you do unfortunately turn out to be HIV positive then assessment and the possibility of treatment is hugely beneficial and will allow a normal lifespan

I put it behind me cause I believed 4th gen tests are conclusive after six weeks, even earlier as per your website yes - I agree - but you have had a known high risk exposure with a man who came inside you who is now known to be HIV positive and NOT on medication = possibility of lots of virus in his semen. You now have a suspicious condition which may - or hopefully may not - be related to HIV. There are a multitude of other conditions (which I'm not going to list or get into a conversation about) which more frequently cause oral thrush than HIV - but because of your exposure etc as above I would do exactly the same as your GP

Don't you think that it's a bit early - after 12 months - to develop thrush because of HIV?no

Lastly, what went wrong with the testing and possibly didn't pick up the infection? Have you seen a negative result at seven weeks to turn positive later on?No - I haven't seen the scenario you describe - what I have seen is where people on reflection have their dates etc or the events muddled and the result has changed. We don't know that the test has failed - what your GP and I are concerned about is a very suspicious sequence which includes accidentally unprotected sex with another male who is not on meds and is HIV positive with a subsequent appearance of thrush - the COMBINATION of those events mean that re-testing is necessary

Does the thrush means that I have to start medication asap?again, we don't KNOW the position yet. If you are HIV positive - then further tests need to be done - if these show that your T cell count is very low and your viral load is high then medication is advised. But - we don't KNOW the answer yet - which is why you should retest. If you are HIV positive then treatment at some point will be lifesaving and restore normality for you.
best regards, Sean
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