I'm 32 years healthy male, I have had unprotected vaginal sex with a women that told me lately that she is poz for 2 years now and she is untreated yet, after 15 days, I had fever of 37.7 C for more than 3 weeks ,muscle pain, white tong, big mouth canker , diarrhea and blood in stool, Tingling in all my body and a rash on my back, very painful swollen Swollen glands throughout my whole body .II have been in hospital 5 times during the last 3 months, had blood tests at week 12 my CD4/CD8 rate are nearly 1 ( CD4 count are 920, DC8 780, a report of 1.20. ) they also found an extremely high rate of CMV IgG, (512 U / ml, the limit is 15 and IgM negative) and high levels of EBV IgG and IgM negative
I am experiencing, the same symptoms till today (nearly 4 and half months after exposure) specially very white tongue, and enlarged generalized lymp nodes, even in my chest there is lymph nodes that are tender.
After the severe sore throat of about two months then a severe flu-like that lasted 10 days, my wife is feeling right, now. We have both very white tong.
I had two different advices from two well known HIV expert:
.
Doc BOB (the body): Repeating test at 6 months mark is more than warranted, and there is a possibility that the test will change.
Doc Handsfied (medhelp): Conclusive. No further tests are required, the test will not change.
My questions are :
1- Could the tests done up to 12 weeks have missed my infection,
2- My CMV, and EBV PCR at week 12 after exposure were bellow detection, so, that we are experiencing now me and my wife, are not due those viruses.
Could I have a mutant HIV strain, not detected by Elisa DUO, knowing that the lady I had sex with, was diagnosed as HIV+ by Elisa test.
3- All my blood work show that I am fighting an infection, but my blood sedimentation ESR is nil, after one and two hours, my docs say that only HIV that can make it nil. Is it true in your opinion, have you seen this in HIV acute infection ?
4- MY CD4 is 992, CD8 720 (HIGH), rapport 1.2, nearly 1, is my CD8 high value, and low CD4/CD8 repport, are evidence that I am experiencing Acute HIV infection. of it can be the case for other infections
5- Is PCR warranted ?
6- if I was your patient, what will you recommend ? will you suggest that I go for 6 months test, if yes, What is our odds to be HIV - in the next 6 months test despite all he clear evidences (labs tests and symptomes) that we are indeed infected ?
I know my post is too long and too much questions, but my case is complicated and the two world well known expert have different opinion. As HIV leaders expert, and very fammiliar with DUO test your opinion will make a difference in my case.
Hello,
Thank you very much for your post and welcome to our forum.
I am going to try to answer all your questions here below:
1- Could the tests done up to 12 weeks have missed my infection,
No, I believe that you are negative without any doubt.
2- My CMV, and EBV PCR at week 12 after exposure were bellow detection, so, that we are experiencing now me and my wife, are not due those viruses.
Exactly as your IgM levels are undetectable and the positive IgG for CMV would indicate an infection in the past
Could I have a mutant HIV strain, not detected by Elisa DUO, knowing that the lady I had sex with, was diagnosed as HIV+ by Elisa test.
Not at all. It would have been detected by either the presence of antibodies or the presence of the antigen p24.
3- All my blood work show that I am fighting an infection, but my blood sedimentation ESR is nil, after one and two hours, my docs say that only HIV that can make it nil. Is it true in your opinion, have you seen this in HIV acute infection ?
The blood test that you mention do not indicate evidence of acute infection, unless the total white cell count was elevated with a specific deviation in the differential; you have not mentioned this. Also the fact that the ESR is also normal would exclude most acute infections; the statement about HIV is not necessarily true and can be elevated during acute sero-conversion
4- MY CD4 is 992, CD8 720 (HIGH), rapport 1.2, nearly 1, is my CD8 high value, and low CD4/CD8 repport, are evidence that I am experiencing Acute HIV infection. of it can be the case for other infections
The most important factors are the CD4/CD8 ratio and the CD4 percentage of the whole white blood cell count, as this fluctuates constantly as we fight infections and not only HIV. Your levels are within normal range, CD4 count is between 440 and 1470, and CD8 count between 290 and 1,050. The normal CD4/CD8 ratio is within 0.54 and 2.97; I calculated your ratio wihich is 1.37, completely normal.
5- Is PCR warranted ?
Not at all. It will be negative.
6- if I was your patient, what will you recommend ? will you suggest that I go for 6 months test, if yes, What is our odds to be HIV - in the next 6 months test despite all he clear evidences (labs tests and symptomes) that we are indeed infected ?
You do not need any further investigations regarding HIV. Your symptoms and test results are NOT evidence of HIV infection at all whatosever.
cjust to ad, my the total white cell count start to rise since my first blood work at week 6, at weeks 12 it was slightly elevated than the upper limites (43 the limites 40). is that an indication of an hiv infection as you stated in your coments. ?
Thank you very much for your answer
I would like just to add information to question 3, my white blood cel are higher that the limites (43 and the upper limite is 40)
I have oral and what look like genital warts.
and as I said generalized swoolen lymph nones, neck, arm pit, groin, even in the face and behind the knee. all my lymph are swollen ater this unprotected intercourse with this HIV+ female. still till now about 5 months.
my GP said that my high white blood cell, show that I am fighting a virus, and with all the details in my first question and my wife same symptomes as mine. would you please tell me i you still not recomend a urther testing, as we are planning to have baby, I need to be sure 100 % beore engaging in such project.
A raised white blood cell is a very common feature and is not characteristic of HIV infection. You might be indeed fighting a virus, but from all the information that you have given, I can assure you that it is not HIV.
Best wishes,
José
Am I and my wife really HIV- !
Linear Mode
